tLyP-1 peptide (Targeted LyP-1 peptide) is a functionalized short peptide consisting of 7 amino acids, with the sequence CGNKRTR, derived from the structural optimization of the LyP-1 peptide. This peptide specifically interacts with Neuropilin-1 (NRP-1) and is widely used in NRP-1-targeting molecular probes, nano-delivery systems, and radiopharmaceutical-related research.

tLyP-1 contains a CendR-related structural motif and can serve as a functionalized targeting ligand conjugated to various carriers or imaging molecules, providing a research tool for tumor-related studies, molecular imaging, and delivery system development.

I. Basic Information

II. Structural Characteristics and Mechanism of Action

1. tLyP-1 Short Peptide Structure – Providing NRP-1 Recognition Capability
tLyP-1 consists of 7 amino acids, and its specific sequence structure enables interaction with NRP-1-related domains, providing a ligand basis for constructing NRP-1-targeting functional molecules.

2. CendR-Related Structure – Supporting Tissue Penetration Studies
tLyP-1 contains CendR-related sequence features, making it suitable for studying receptor-mediated cellular uptake and tissue penetration processes, with application value in nano-delivery and molecular probe development.

3. Modular Modification Capability – Facilitating Functional Expansion
Through chemical conjugation, tLyP-1 can be linked to fluorescent dyes, radionuclides, drug molecules, and nanocarriers for constructing different types of functionalized research systems.

III. Main Applications

1. Construction of NRP-1-Targeting Delivery Systems
tLyP-1 can be used to modify delivery carriers such as liposomes, polymeric nanoparticles, and micelles for studying targeted delivery strategies of drug molecules, nucleic acids, and imaging probes.

2. Development of Molecular Imaging Probes
By conjugating with fluorescent dyes or radiolabeling groups, tLyP-1 can be used to construct NRP-1-related imaging probes, supporting cellular imaging, tissue distribution, and target site studies.

3. Tumor Microenvironment Research
tLyP-1 can serve as a tool for NRP-1 functional studies, including receptor expression analysis, cellular uptake mechanism investigation, and tumor microenvironment exploration.

4. Radiopharmaceutical Precursor and Functionalized Ligand Research
tLyP-1 can serve as a targeting ligand module, combining with radionuclide labeling groups or other functional structures for molecular design research in nuclear medicine.

IV. Related Radiopharmaceutical Precursor Products