I. Basic Introduction

mPEG-CH2CH2CH2-NH2, namely Methoxy Polyethylene Glycol Propylamine, is a linear monofunctional polyethylene glycol (PEG) derivative. One end is capped with a methoxy group (-OCH₃), while the other end is connected via three methylene groups (-CH2CH2CH2-) to a primary amine group (-NH₂), endowing the PEG chain with further conjugation capabilities.

Compared to mPEG-NH2, where the amino group is directly attached, mPEG-CH2CH2CH2-NH2 features a propyl spacer arm between the PEG chain and the amino group. This provides greater structural flexibility and helps reduce steric hindrance, facilitating subsequent conjugation reactions.

mPEG-CH2CH2CH2-NH2 combines the excellent hydrophilicity and biocompatibility of PEG with the reactivity of the amino group, making it suitable for research applications in bioconjugation, drug delivery, and nanomaterial surface modification.

Basic Information:

• English Name:Methoxy Polyethylene Glycol Propylamine

• Abbreviation:mPEG-CH2CH2CH2-NH2

• CAS Number:116164-53-5

• Structural Features:Methoxy-capped PEG chain + Propyl linker arm + Terminal primary amine group

• Functional Group:Amino group (-NH₂)

II. Structural Features and Mechanism of Action

1. Linear Single-Ended PEG Structure
mPEG-CH2CH2CH2-NH2 is a linear monofunctional PEG derivative. One end of the PEG chain is capped with a methoxy group to maintain its single-ended functionality, while the other end is linked to a reactive amino group, allowing further conjugation with different functional molecules.

The propyl spacer arm (-CH2CH2CH2-) between the PEG chain and the amino group imparts greater flexibility and accessibility to the terminal functional group, which facilitates modification of target molecules.

2. Amino Coupling Reactions
The terminal primary amine exhibits good reactivity and can be used for molecular conjugation through various chemical reactions, including:

• Amidation:Reacts with carboxylic acids, NHS esters, etc., to form stable amide bonds.

• Alkylation:Couples with aldehydes, halides, etc.

• Other amine-reactive systems:Used to construct PEG-linked structures.

Through these reactions, mPEG-CH2CH2CH2-NH2 enables the conjugation of PEG to proteins, peptides, small-molecule drugs, fluorescent dyes, and nanomaterials.

3. Functional Role of the PEG Chain
The PEG segment provides good hydrophilicity, improving the modified molecules in terms of:

• Water solubility

• Dispersibility and stability

• Biocompatibility

• Resistance to non-specific adsorption

Therefore, mPEG-CH2CH2CH2-NH2 serves as a versatile PEG linker for biomolecular modification and material functionalization.

III. Main Applications

1. PEGylation of Proteins and Peptides
mPEG-CH2CH2CH2-NH2 can be used for PEGylation of proteins, antibodies, peptides, and other biomacromolecules. The introduction of the PEG chain improves solubility and stability, with applications in bioconjugation and protein modification research.

2. Drug Delivery Systems
Leveraging the hydrophilicity and biocompatibility of the PEG chain, mPEG-CH2CH2CH2-NH2 can be employed in constructing nanocarriers, drug conjugates, and other delivery systems, improving carrier dispersibility and system stability through PEG modification.

3. Surface Functionalization of Nanomaterials
mPEG-CH2CH2CH2-NH2 can be used to modify the surfaces of gold nanoparticles, quantum dots, magnetic nanoparticles, and other materials, enhancing their dispersibility in aqueous environments while providing active sites for further conjugation with functional molecules.

4. Bioprobes and Functional Materials
Utilizing the amino group's ability to couple with fluorescent dyes, biotin, nucleic acid probes, and other molecules, mPEG-CH2CH2CH2-NH2 can be used to prepare fluorescently labeled molecules, bioanalytical tools, and functionalized materials.

IV. Related PEG Derivatives

V. Product List

Sinopeg offers mPEG-CH2CH2CH2-NH2 products in various molecular weight specifications to meet different experimental requirements.

Common molecular weights available include:2K, 5K, 10K, 12K, 20K, 40K, etc.

For more product specifications and detailed information, please visit the Sinopeg official website.

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