I. Basic Introduction

mPEG-NH₂, namely Methoxy Polyethylene Glycol Amine, is a linear monofunctional polyethylene glycol (PEG) derivative. One end is capped with a methoxy group (-OCH₃), while the other end features a reactive amino group (-NH₂), enabling further conjugation and modification capabilities of the PEG chain.

mPEG-NH₂ combines the excellent hydrophilicity and biocompatibility of PEG with the good reactivity of the amino group, making it a commonly used PEG modification reagent in fields such as bioconjugation, drug delivery, and nanomaterial surface functionalization.

Basic Information:

II. Structural Characteristics and Mechanism of Action

1. Linear Monofunctional PEG Structure
mPEG-NH₂ is a typical monofunctional PEG derivative. One end of the PEG chain is capped with a methoxy group to prevent non-specific reactions, while the other end retains a reactive amino group for further conjugation with various functional molecules.

This "one-end protected, one-end activated" structure allows mPEG-NH₂ to achieve targeted modification of target molecules while maintaining the water solubility and stability of PEG.

2. Amino Group Reactive Modification
The terminal amino group (-NH₂) possesses high chemical reactivity and can participate in:

• Amidation reactions:Reacting with carboxylic acids, etc., to form stable amide bonds;

• Alkylation reactions:Coupling with aldehydes, halides, etc.;

• Isocyanate reactions:Forming stable linkages;

Through these reactions, covalent conjugation of PEG chains with proteins, peptides, small molecule drugs, fluorescent dyes, and nanomaterials can be achieved.

3. Functional Role of the PEG Chain
The PEG segment can improve the following properties of the modified molecule: water solubility and dispersion stability, biocompatibility, blood circulation stability, and resistance to protein adsorption. Therefore, mPEG-NH₂ often serves as an important linker in PEGylation studies of biomolecules.

III. Main Applications

1. PEGylation of Proteins and Peptides
mPEG-NH₂ can be used for the PEG modification of proteins, antibodies, peptides, and other biomacromolecules. Introducing PEG chains improves their solubility, stability, and in vivo circulation time. It is commonly used in long-acting protein drug development and bioconjugation research.

2. Drug Delivery Systems
Leveraging its excellent hydrophilicity and biocompatibility, mPEG-NH₂ can be used to construct lipid nanoparticles (LNPs), polymeric nanocarriers, and drug conjugate systems. PEG modification enhances the stability of nano-delivery systems and improves the in vivo delivery performance of drugs.

3. Nanomaterial Surface Functionalization
mPEG-NH₂ can modify the surface of materials such as gold nanoparticles, quantum dots, and magnetic nanoparticles. This enhances their water dispersibility, reduces non-specific adsorption, and provides active sites for further conjugation with targeting ligands.

4. Bioprobes and Detection Technologies
Utilizing the coupling ability of the amino group with molecules like fluorescent dyes, biotin, and nucleic acid probes, mPEG-NH₂ can be used to prepare fluorescent labeling probes, biosensors, and molecular tracing tools.

IV. Related PEG Derivatives

V. Product List
Sinopeg offers mPEG-NH₂ products in various molecular weights to suit different application requirements.

Common molecular weight specifications include: 2K, 3K, 5K, 10K, 20K, 30K, 40K, 50K, etc.

For more product specifications and detailed information, please visit the Sinopeg official website.

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